Genetika 2024 Logo
10th Congress of the Genetic Society of Slovenia &
10th Meeting of the Slovenian Society for Human Genetics

Congress program

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Wednesday 25/9/2024

12:30 - 14:00
Registration
14:00 - 14:15
Opening speech

Maja Čemažar (OI LJ) & Damjan Glavač (MF, UNI LJ)

14:15 - 15:00
PLENARY LECTURE:
Chair: Maja Čemažar (OI LJ)

Plenary Lecture:

Expanding the therapeutic index of adoptive T cell therapy for solid cancer | Daniel J. Powell Jr. (University of Pennsylvania, USA)

15:00 - 16:30
Section I: Genetic diseases I
Session chairs: Damjan Glavač (MF, UNI LJ) & Metka Ravnik Glavač (MF, UNI LJ)

Invited Lecture:

Integration of biomechanical and biochemical risk factors in glaucoma: TGFß2 and TRPV4 | David Križaj (University of Utah, USA)

Invited Lecture:

Postnatal cortical development and regeneration in opossum (Monodelphis domestica): potential connection with neurodegenerative diseases | Jelena Ban & Miranda Mladinić Pejatović (University of Rijeka, HR)

ST1:

Influence of genetic variability of inflammatory pathways on the susceptibility and course of spinal muscular atrophy | Maruša Barbo

ST2:

Transcriptomic profiling and comparative analysis of EA.HY926 and HMEC-1 endothelial cell lines: investigating the impact of calcium electroporation and Ca2+ signaling | Barbara Lisec

16:30 - 17:00
Coffee break
17:00 - 18:30
Section II: Genetic diseases II
Session chairs: Nadja Kokalj Vokač (UKC MB) &  Maruša Debeljak (Pediatrična klinika UKC LJ)

Invited Lecture:

The use of NGS for the diagnosis of rare diseases | Maruša Debeljak

Invited Lecture:

The effects of irradiation on tumour endothelial cells | Boštjan Markelc (OI LJ)

ST1:

Distinction of athlete's heart and cardiomyopathy in asymptomatic young athletes | Špela Stangler Herodež

ST2:

Comprehensive genetic analysis of slovenian families with multi-generational orofacial clefts | Nataša Karas Kuželički

19:00
Welcome reception

Thursday 26/9/2024

08:30 - 09:00
KEYNOTE LECTURE:
Chair: Tanja Kunej (BF, UNI LJ)

Keynote Lecture:

Enhancing AI-based Chemical Screens for 'Undruggable' Cancer Targets Using Quantum Models | Igor Štagljar (University of Toronto)

09:00 - 10:30
Section III: Cancer genetics
Session chairs: Boštjan Markelc (OI LJ) & Barbara Breznik (NIB)

Invited Lecture:

Genetic predisposition to cancer - the use of genetic tests in the assessment of cancer risk | Mateja Krajc (OI LJ)

Invited Lecture:

Slovenian contribution to discovery of novel genes for human genetic disorders | Aleš Maver (UKC LJ)

ST1:

Spatial transcriptomics on glioblastoma organoid model as a personalized tool for therapy research response | Metka Novak

ST2:

Markers of HPV-positive and HPV-negative squamous cell carcinoma of the larynx, identified by in situ spatial profiling of RNA targets | Emanuela Boštjančič

10:30 - 11:00
Coffee break
11:00 - 12:30
Section IV: Gene and Cell Therapy
Session chairs: Simona Kranjc Brezar (OI LJ) & Anže Smole (NIB)

Invited Lecture:

Developing vaccines based on DNA-electroporation: advantages and pitfalls | Luigi Aurisicchio (Takis Biotech)

ST1:

Treatment of skin tumors with intratumoral interleukin 12 gene electrotransfer in the head and neck region: a first-in-human clinical trial | Gregor Sersa

ST2:

Unlocking regulatory T cell potential: from ex vivo expansion to single cell profiling | Jelka Pohar

ST3:

The iToci story: autonomous amelioration of cytokine release syndrome by CAR-T cells | Anže Smole

ST4:

Modulation of canine adipose-derived mesenchymal stem / medicinal signaling cells with ascorbic acid: effect on proliferation and chondrogenic differentiation on standard plastic and silk fibroin surfaces | Metka Voga

12:30 - 13:30
Lunch
13:30 - 15:00
Section V: Pharmacogenomics
Session chairs: Vita Dolžan (MF, UNI LJ) & Uroš Potočnik (MF, UM)

Invited Lecture:

Pharmacogenetic precision dosing in polypharmacy - genotyping or phenotyping? | Julia Carolin Stingl (University Bonn)

ST1:

Molecular biomarkers for personalized treatment of malignant mesothelioma | Katja Goričar

ST2:

Single-cell transcriptomic and targeted genomic profiling reveal CRTAM and PLCB1 as novel HUB genes for anti-TNFα therapy response in Crohn's disease | Mario Gorenjak

ST3:

Transcriptomic analysis of immune response to intratumoral delivery of control plasmid dna via gene electrotransfer using two pulse protocols in colon cancer | Tim Božič

ST4:

The ENST00000374459 RasGEF1A isoform downregulation identified by isoform-level transcriptomics in PBMCs of breast cancer patients is associated with tumor proliferation and ctDNA shedding | Helena Čelešnik

15:00 - 16:00
Section VI: Animal genetics
Session chairs: Simon Horvat (BF, UNI LJ), Elena Bužan (UP FAMNIT)

Invited Lecture:

Genomics tools enhance wildlife conservation and management | Elena Bužan (UP FAMNIT)

ST1:

Back from the brink: genetic erosion, genetic rescue, and long-term management of the reintroduced Dinaric Lynx (Lynx Lynx) population | Tomaž Skrbinšek

ST2:

Genetic elements in the genome of Choloepus didactylus associated with reproduction, bisynthesis of mitochondria and lactation | Peter Dovč

ST3:

Maternal effect: transcriptome differences in unfertalized EGGS between wild and hatchery grayling (T. thymallus) | Jernej Bravničar

ST1:

Effect of raly gene on coat colour in equids | Jelena Kotiščak

16:30 - 17:00
Coffee break
17:00 - 18:30
Section VII: Genome analysis and bioinformatics
Session chairs: Tanja Kunej (BF, UNI LJ) & Tomaž Curk (FRI, UNI LJ)

Invited Lecture:

The Slovenian genome project | Borut Peterlin

ST1:

ProBiS tools: bridging sequences to structures for unraveling harmful variants in protein binding sites | Janez Konc

ST2:

Transcription-decay decomposition of mRNA dynamics as an autoencoder loss function | Martin Špendl

ST3:

European genomic data infrastructure (GDI) PROJECT with the USECASE: Genome of EUROPE | Lucija Raspor DallOlio

ST4:

Spatial transcriptomics discoveries of human pathologies using xenium analyzer | Kaja Blagotinšek Cokan

19:00
POSTER SESSION - poster viewing

Friday 27/9/2024

08:30 - 09:00
KEYNOTE LECTURE:
Chair: Boštjan Markelc (OI LJ)

Keynote Lecture:

Microphysiological platforms for modeling and treating rare and inherited vascular diseases | William J. Polacheck (UNC Chapel Hill, NC State University, USA)

09:00 - 10:30
Golden chromosome 1: Transciptomics
Session chairs: Maja Čemažar (OI LJ) and Damjan Glavač (MF, UNI LJ)

GC1:

Complete transcriptome analysis reveals the impact of a vitamin A-enriched diet on urothelial proliferation in cyclophosphamide-induced acute cystitis | Brina Dragar

GC2:

RNA-seq analysis of skin sampled by non-invasive tape strips revealed differences between trunk, extremities and scalp psoriasis | Martina Krušič 

GC3:

Integrating automated and manual annotation techniques for accurate cell type identification in single-cell RNA sequencing data | Gloria Krajnc

GC4:

Identification of mastitis resistance candidate genes in ruminants | Zala Brajnik Kovačič

GC5:

Methylation markers for characterization and determination of the cancer origin in liver adenocarcinomas | Tina Draškovič 

GC6:

In vitro evaluation of mRNA gene electrotransfer in B16F10 and CT26 cells | Ajda Medved

10:30 - 11:00
Coffee break
11:00 - 12:30
Golden chromosome 2: Molecular population genetics
Session chairs: Branka Creegen Javornik (BF, UNI LJ) & Peter Dovč (BF, UNI LJ)

GC7:

Whole genome sequencing of composite populations of common bean (Phaseolus Vulgaris L.) differing in seed coat colour | Eva Plestenjak

GC8:

Genetic variability in a Slovenian cohort of patients with erythrocytosis | Aleša Kristan

GC9:

Metabarcoding analysis of wild boar (Sus scrofa) dietary preferences at rooting sites | Aja Bončina

GC10:

Irradiation-induced immunologically relevant molecular and transcriptional changes in tumor endothelial cells | Iva Šantek

GC11:

Use of in vitro and in vivo osteosarcoma models for evaluation of electrochemotherapy | Saša Kupčič

GC12:

Ecotype as a conservation unit: Danubian lacustrine brown trout (Salmo Trutta) | Gašper Renko

12:30 - 13:30
Lunch
13:30 - 15:00
Section VIII: Plant genetics
Session chairs: Jernej Jakše (BF, UNI LJ) & Jana Murovec (BF, UNI LJ)

Invited Lecture:

Role of small RNAs in interactions between pathogens and host plants | Nataša Štajner (UL BF)

Invited Lecture:

Unravelling potato abiotic stress responses using omics technologies | Marko Petek (NIB)

ST1:

Citizen science approach to science: common bean example | Barbara Pipan

ST2:

New achievements in the selection of promising genotypes in Helichrysum Italicum (Roth) G. Don in Slovenia | Alenka Baruca Arbeiter

15:00 - 19:00
Free afternoon
19:00
Conference dinner

Saturday 28/9/2024

09:00 - 10:30
Section IX: Environment and forensic genetics
Session chairs: Jelka Zabavnik Piano (VF, UNI LJ) & Tomaž Skrbinšek (BF, UNI LJ)

Invited Lecture:

Animal forensic genetics in Hungary - challenges and developments | Petra Zenke (Uni Vet Med Budapest, Hungary)

ST1:

From animal diet analysis to human food authentication: how DNA metabarcoding techniques used in ecological studies can help ensure food security | Tomaž Skrbinšek

ST2:

Environmental DNA, camera traps and citizen science app for biodiversity monitoring | Luka Duniš

ST3:

Development of CRISPR/CAS detection method for viroids in hops | Tanja Guček

ST4:

Species identification in different field samples of exotic animal species | Saša Koprivec 

10:30 - 11:00
Coffee break
11:00 - 12:30
Section X: Microbial genetics
Session chairs: Tomaž Accetto (BF, UNI LJ) & Marjanca Starčič Erjavec (BF, UNI LJ)

Invited Lecture:

Control of Bacillus subtilis by phage regulatory switches | Anna Dragoš (BF, UNI LJ)

Invited Lecture:

Correlations between virulence-associated genes, LPS type and biofilm forming abilities of selected Escherichia coli strains | Marjanca Starčič Erjavec

ST1:

Characterization of the microbial community of olive leaves affected by olive leaf spot disease | Matjaž Hladnik

ST2:

Transcriptomic analysis of polysaccharide utilization loci reveals substrate preferences in ruminal generalists Segatella bryantii TF1-3 and Xylanibacter ruminicola KHP1 | Urška Murovec

12:30 - 13:30
Lunch
13:30 - 14:15
CLOSING LECTURE:
Chairs: Damjan Glavač (MF, UNI LJ) & Simon Horvat (BF, UNI LJ)

Closing Lecture:

Biomedical data science in the age of AI | Blaž Zupan (FRI, UNI LJ, Baylor College)

14:15 - 16:30
Awards and closing remarks SGD Assembly

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